HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-Phenyl-(1,2,4)thiadiazol-5-yl)-piperazine → 4-Cyclopentyloxy-N-methyl-3-[4-(3-phenyl-[1,2,4]thiadiazol-5-yl)-piperazine-1-carbonyl]-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-Phenyl-(1,2,4)thiadiazol-5-yl)-piperazine | HCID 2777760 | — |
| Reactant | HCID 21100227 | HCID 21100227 | — |
| Product | 4-Cyclopentyloxy-N-methyl-3-[4-(3-phenyl-[1,2,4]thiadiazol-5-yl)-piperazine-1-carbonyl]-benzenesulfonamide | HCID 21100163 | 72% |
Reaction Steps
Prepared in analogy to example 1 (b) from 2-cyclopentyloxy-5-methylsulfamoyl-benzoic acid (Example A29) and 3-phenyl-5-piperazino-1,2,4-thiadiazole. The crude material was purified by chromatography (SiO2, methanol/dichloromethane) to yield the title compound as an off-white solid (yield 72%). MS (m/e): 528.5 (M+H+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220744B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-0deb2a2d6ad44244ad2d57d3fae52bb9 |
| Source note | uspto-grants-2007_05 |