反应详情

Nicotinoyl chloride (1.1 eq) was added to a solution of N-(2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)-N-phenylacetamide (100 mg) and N-ethyl-N,N-diisopropylamine (2.2 eq) in dioxane (1 ml). The mixture was stirred overnight at room temperature. Dichloromethane was added and the organic layer was washed by water and sodium carbonate solution and dried over sodium sulfate. The solvent was removed and the mixture was purified by chromatography on silica gel (dichloromethane and ethanol (99:1)) to afford the title compound (30 mg).

1. washthe organic layer was washed by water and sodium carbonate solution
2. dry with materialdried over sodium sulfate
3. customThe solvent was removed
4. customthe mixture was purified by chromatography on silica gel (dichloromethane and ethanol (99:1))