反应详情

The crude product from Step A was dissolved in a MeOH/H2O mixture (2:1, 4 ml). 0.7 g KOH was added to the solution and heated at reflux for 1.5 h. Then the reaction mixture was neutralized with 1M HCl, a small amount of water was added and the mixture extracted with ethyl acetate. The solvent was evaporated. The product was purified by chromatography (SiO2; ethyl acetate). The yield was 40%.

1. temperatureheated
2. temperatureat reflux for 1.5 h
3. extractionthe mixture extracted with ethyl acetate
4. customThe solvent was evaporated
5. customThe product was purified by chromatography (SiO2; ethyl acetate)