HCID 21913050, compound → HCID 69182845, compound

HRID 1352530Notes

Reaction equation

HRID 1352530 reaction equation
[CH3:1][C:2]1[C:7]([CH3:8])=[C:6]([NH:9][CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:5]([N+:19]([O-])=O)=[C:4]([O:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[N:3]=1.[H][H]>[Pt].C1(C)C=CC=CC=1>[CH3:8][C:7]1[C:6]([NH:9][CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:5]([NH2:19])[C:4]([O:22][C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)=[N:3][C:2]=1[CH3:1]

Participants

5

Reactant 2

HCID 21913050HCID 21913050, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 69182845HCID 69182845, compound

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalyst2×HCID 1140TolueneSolvent

Procedure

Anhydrous toluene (100 ml), 5% platinum on carbon (Pt/C) (1.5 g), and 2,3-dimethyl-5-nitro-6-phenoxy-N-(2-phenoxyethyl)pyridin-4-amine (2.97 g) from Part C were placed in a Parr hydrogenation flask at a hydrogen pressure of 345 kPa for 4 hours with shaking. Additional 5% Pt/C (1.5 g) was added and the reaction was allowed to continue for 3 hours. The reaction mixture was filtered through a fluted filter paper and then through a folded No. 2 Whatman filter. The solvent was removed from the filtrate under reduced pressure and the resulting oil was used in the next step.

Workup

  1. filtrationThe reaction mixture was filtered through
  2. filtrationa fluted filter paper
  3. filtration2 Whatman filter
  4. customThe solvent was removed from the filtrate under reduced pressure

Sources & evidence

ORD record
ord-9534c0e5bbfb45e5955080d218a39f7f
Source dataset
uspto-grants-2007_05
Patent number
US07220758B2

Reaction notes

Loading…