HCID 21913573, compound → HCID 85898826, compound

HRID 1352533Notes

Reaction equation

HRID 1352533 reaction equation
[Cl:1][C:2]1[C:7]([N+:8]([O-])=O)=[C:6]([NH:11][CH2:12][CH2:13][O:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:5]([CH3:21])=[C:4]([CH3:22])[N:3]=1.[H][H]>[Pt].C1(C)C=CC=CC=1>[Cl:1][C:2]1[C:7]([NH2:8])=[C:6]([NH:11][CH2:12][CH2:13][O:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:5]([CH3:21])=[C:4]([CH3:22])[N:3]=1

Participants

5

Reactant 2

HCID 21913573HCID 21913573, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 85898826HCID 85898826, compound

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 1140TolueneSolvent

Procedure

Toluene (150 ml), 5% platinum on carbon (5.0 g), and 2-chloro-5,6-dimethyl-3-nitro-N-(2-phenoxyethyl)pyridin-4-amine (3.32 g) from Part B of Example 1 were placed in a Parr hydrogenation flask at a hydrogen pressure of 345 kPa for 4 hours with shaking. HPLC analysis indicated that the reaction was complete. The reaction mixture was filtered through a fluted filter paper and then through a folded No. 2 Whatman filter. The solvent was removed from the filtrate under reduced pressure and the resulting brown oil was used in the next step.

Workup

  1. filtrationThe reaction mixture was filtered through
  2. filtrationa fluted filter paper
  3. filtration2 Whatman filter
  4. customThe solvent was removed from the filtrate under reduced pressure

Sources & evidence

ORD record
ord-9ec154ad656f4b309f566915031f235c
Source dataset
uspto-grants-2007_05
Patent number
US07220758B2

Reaction notes

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