反应详情

A suspension of methyl 2-ethoxy-4-acetamidobenzoate (50 g, 211 mmol) in aqueous solution of NaOH (15% W/W, 200 ml) was gently refluxed for 16 hours. The resulting pale brown solution was allowed to cool to room temperature and then further cooled in an ice water bath. Concentrated HCl (37% w/w) was added until the solution reached a pH of 6. The solid precipitated from the solution was filtered under vacuum, dried at 50° C. to give 38.3 g of the title compound (yield 100%).

1. temperaturewas gently refluxed for 16 hours
2. temperaturefurther cooled in an ice water bath
3. customThe solid precipitated from the solution
4. filtrationwas filtered under vacuum
5. customdried at 50° C.