Hydrochloric Acid → HCID 15512070, compound

HRID 1352668Notes

Reaction equation

HRID 1352668 reaction equation
Cl[C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[F:8][C:9]1[CH:26]=[CH:25][C:12]([O:13][CH2:14][C@H:15]2[CH2:24][N:19]3[CH2:20][CH2:21][NH:22][CH2:23][C@@H:18]3[CH2:17][CH2:16]2)=[CH:11][CH:10]=1.Cl>>[F:8][C:9]1[CH:10]=[CH:11][C:12]([O:13][CH2:14][C@H:15]2[CH2:24][N:19]3[CH2:20][CH2:21][N:22]([C:2]4[N:7]=[CH:6][CH:5]=[CH:4][N:3]=4)[CH2:23][C@@H:18]3[CH2:17][CH2:16]2)=[CH:25][CH:26]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 744042-ChloropyrimidineHCID 53849828HCID 53849828, compound

Product 1

HCID 15512070HCID 15512070, compound

Procedure

The title compound was prepared according to Preparation 3 with 2-chloropyrimidine and (7R,9aS)-7-(4-fluorophenoxy)methyl-2,3,4,6,7,8,9,9a-octahydro-1H-pyrido[1,2-a]pyrazine (Preparation 8). mp (.HCl) 283–285° C. HRMS calcd for C19H23FN4O: 342.1856; found: 342.1867.

Sources & evidence

ORD record
ord-d29dd4146aed4dd7a3a18f9c0360254b
Source dataset
uspto-grants-2007_05
Patent number
US07220753B2

Reaction notes

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