Hydrochloric Acid → HCID 21997246, compound

HRID 1352674Notes

Reaction equation

HRID 1352674 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=1.[OH:9][CH2:10][CH:11]1[CH2:20][N:15]2[CH2:16][CH2:17][NH:18][CH2:19][CH:14]2[CH2:13][CH2:12]1.[C:21]1(O)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.Cl>>[O:9]([CH2:10][CH:11]1[CH2:20][N:15]2[CH2:16][CH2:17][N:18]([C:2]3[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=3)[CH2:19][CH:14]2[CH2:13][CH2:12]1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 996PhenolHCID 276852,5-DichloropyridineHCID 12985539(Octahydro-1H-pyrido[1,2-A]pyrazin-7-YL)methanol

Product 1

HCID 21997246HCID 21997246, compound

Procedure

The title compound was prepared according to Example 15 using 2,5-dichloropyridine, (7RS,9aSR)-7-hydroxymethyl-2,3,4,6,7,8,9,9a-octahydro-1H-pyrido[1,2-a]pyrazine (U.S. Pat. No. 5,326,874), and phenol. mp (.HCl) 218–224° C. 13C NMR (base, CDCl3): δ 27.0, 29.1, 36.4, 45.3, 50.9, 54.6, 58.8, 60.5, 70.9, 107.8, 114.5, 120.1, 120.7, 129.4, 137.1, 146.2, 157.6, 159.0. Anal. calcd for C20H24ClN3O C, 67.12; H, 6.76; N, 11.74; found: C, 67.22; H, 6.85; N, 11.49.

Sources & evidence

ORD record
ord-4f73e72bb8e14a2ea6cac3c5ee23c506
Source dataset
uspto-grants-2007_05
Patent number
US07220753B2

Reaction notes

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