HCID 13524712, compound → HCID 20654283, compound

HRID 1352698Notes

Reaction equation

HRID 1352698 reaction equation
C(Cl)(=O)C(Cl)=O.CS(C)=O.[F:11][C:12]1[CH:17]=[CH:16][C:15]([CH:18]([CH:20]2[CH2:35][N:24]3[CH2:25][CH2:26][N:27]([C:29]4[N:34]=[CH:33][CH:32]=[CH:31][N:30]=4)[CH2:28][CH:23]3[CH2:22][CH2:21]2)[OH:19])=[CH:14][CH:13]=1>>[F:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]([CH:20]2[CH2:35][N:24]3[CH2:25][CH2:26][N:27]([C:29]4[N:34]=[CH:33][CH:32]=[CH:31][N:30]=4)[CH2:28][CH:23]3[CH2:22][CH2:21]2)=[O:19])=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 13524712HCID 13524712, compoundHCID 20654282HCID 20654282, compound

Product 1

HCID 20654283HCID 20654283, compound

Procedure

The title compound was prepared according to the oxalyl chloride/DMSO oxidation step of Example 46 starting with (4-fluoro)phenyl-[(7RS,9aSR)-2-(pyrimidin-2-yl)-2,3,4,6,7,8,9,9a-octahydro-1H-pyrido[1,2-a]pyrazin-7-yl]-methanol (Example 46). 13C NMR (CDCl3): δ 27.3, 28.3, 48.6, 54.1, 56.7, 59.9, 110.1, 115.77, 116.05, 131.20, 131.32, 132.4, 158.0, 161.1, 163.4, 166.7. HRMS calcd for C19H21FN4O: 340.1699, found: 340.1539.

Sources & evidence

ORD record
ord-0da022006e7c488d9573bd7c847b0036
Source dataset
uspto-grants-2007_05
Patent number
US07220753B2

Reaction notes

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