Hydrochloric Acid → HCID 20654262, compound

HRID 1352709Notes

Reaction equation

HRID 1352709 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]2[CH2:14][C@@H:15]([CH2:18][O:19][C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)[CH2:16][CH2:17][C@@H:10]2[CH2:9]1)(OC(C)(C)C)=O.Cl>C(Cl)(Cl)Cl.C(OCC)C>[F:26][C:23]1[CH:22]=[CH:21][C:20]([O:19][CH2:18][C@@H:15]2[CH2:14][N:11]3[CH2:12][CH2:13][NH:8][CH2:9][C@H:10]3[CH2:17][CH2:16]2)=[CH:25][CH:24]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 22940605HCID 22940605, compound

Product 1

HCID 20654262HCID 20654262, compoundYield 126.1%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6212ChloroformSolvent

Procedure

A solution of 0.44 g (1.2 mmol) of (7S,9aR)-2-BOC-7-(4-fluorophenoxy)methyl-2,3,4,6,7,8,9,9a-octahydro-1H-pyrido[1,2-a]pyrazine in 25 mL of chloroform was treated with excess HCl(g) in ethyl ether and stirred at ambient temperature for 2 h. The solvent was evaporated to give 0.40 g of title compound as the dihydrochloride salt which was used for subsequent reactions without purification.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-e9fa1ddef52d4a0e95c11c315cb2d83a
Source dataset
uspto-grants-2007_05
Patent number
US07220753B2

Reaction notes

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