HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1352802Generated: October 31, 2026
Thionyl Chloride → 4-Chloro-5-chloroformyl-6-methoxy-2-methylthiopyrimidine
https://huagongshe.com/reaction/1352802
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Chloro-6-methoxy-2-(methylsulfanyl)pyrimidine-5-carboxylic acid | HCID 17848363 | — |
| Product | 4-Chloro-5-chloroformyl-6-methoxy-2-methylthiopyrimidine | HCID 17848284 | — |
Reaction Steps
A mixture of 4-chloro-5-carboxy-6-methoxy-2-methylthiopyrimidine (prepared in the above (3)) 2.00 g and thionyl chloride 5 ml is stirred at 40° C. for 15 minutes. Thionyl chloride, etc. is distilled off and the solvent is removed with azeotrope with methylene chloride to give 4-chloro-5-chloroformyl-6-methoxy-2-methylthiopyrimidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07220736B2 |
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| Source dataset | uspto-grants-2007_05 |
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| ORD ID | ord-e22c99a56cd4495b801fa3f2c61e9e5b |
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| Source note | uspto-grants-2007_05 |
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