反应详情

To a solution of lithium aluminum hydride (455 mg, 12 mmol) in tetrahydrofuren was dropped ethyl [3-(acetyloxy)phenoxy]acetate (1.19 g, 5 mmol) in tetrahydrofuran (20 ml) at room temperature, and the mixture was stirred for 2 hours at room temperature. The reaction was quenched by 10% hydrochloric acid and the mixture was extracted with ethyl acetate. The organic layer was washed with water, 10% hydrochloric acid, an aqueous saturated sodium hydrogencarbonate solution and an aqueous saturated sodium chloride solution. The organic layer was dried over sodium sulfate. The solvent was removed under reduced pressure to give 3-(2-hydroxyethoxy)phenol (864 mg, quantitatively).

1. customThe reaction was quenched by 10% hydrochloric acid
2. extractionthe mixture was extracted with ethyl acetate
3. washThe organic layer was washed with water, 10% hydrochloric acid
4. dry with materialThe organic layer was dried over sodium sulfate
5. customThe solvent was removed under reduced pressure