反应详情

温度

0 °C

Lithium aluminum hydride in tetrahydrofuran (1M, 30 mL) was added dropwise to a stirring solution of N-[2-(1H-indol-3-yl)ethylacetyltryptamineacetamide (2.02 g) in tetrahydrofuran (10 mL) at 0° C. The solution was then heated at reflux overnight. The solution was cooled to 0° C. and water was very carefully added dropwise. The white solid was filtered and rinsed with ether/methanol (9:1, 2×25 mL). The solvent was removed from the filtrate, giving N-ethyl-2-(1H-indol-3-yl)ethanamine as a viscous pale yellow oil (1.75 g, 93%).

1. temperatureThe solution was then heated
2. temperatureat reflux overnight
3. filtrationThe white solid was filtered
4. washrinsed with ether/methanol (9:1, 2×25 mL)
5. customThe solvent was removed from the filtrate