N-[4-(dimethylamino)-6-(4-toluidino)-2-pyrimidinyl]-2-phenylacetamide → N4,N4-Dimethyl-N6-(4-methylphenyl)-N2-(2-phenylethyl)-2,4,6-pyrimidinetriamine

HRID 1352895Notes

Reaction equation

HRID 1352895 reaction equation
[CH3:1][N:2]([CH3:27])[C:3]1[CH:8]=[C:7]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][CH:11]=2)[N:6]=[C:5]([NH:17][C:18](=O)[CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:4]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[CH3:27][N:2]([CH3:1])[C:3]1[CH:8]=[C:7]([NH:9][C:10]2[CH:11]=[CH:12][C:13]([CH3:16])=[CH:14][CH:15]=2)[N:6]=[C:5]([NH:17][CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:4]=1

Participants

4

Reactant 2

HCID 21101364N-[4-(dimethylamino)-6-(4-toluidino)-2-pyrimidinyl]-2-phenylacetamideHCID 21226445Aluminium lithium hydride

Product 1

HCID 58863874N4,N4-Dimethyl-N6-(4-methylphenyl)-N2-(2-phenylethyl)-2,4,6-pyrimidinetriamine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of N-[4-(dimethylamino)-6-(4-toluidino)-2-pyrimidinyl]-2-phenylacetamide (60 mg, 0.166 mmol), and LAH (1 mL, 1M in THF) in THF (10 mL) was refluxed for 3 h.

Workup

  1. temperaturewas refluxed for 3 h.

Sources & evidence

ORD record
ord-0b96d9bd71f2448ea12237ff945136c7
Source dataset
uspto-grants-2007_05
Patent number
US07220775B2

Reaction notes

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