反应详情

β-Phenylalanine from II.2a (93) was suspended in ethanol (1.5 l) and the solution was saturated with gaseous HCl at room temperature. It was then heated under reflux for 4 h and stirred overnight at room temperature. The solution was cooled to 5° C. and filtered with suction. The filtrate was concentrated in vacuo, and the residue was washed with ether and dried. A white solid was obtained (yield: 52 g).

1. temperatureIt was then heated
2. temperatureunder reflux for 4 h
3. temperatureThe solution was cooled to 5° C.
4. filtrationfiltered with suction
5. concentrationThe filtrate was concentrated in vacuo
6. washthe residue was washed with ether
7. customdried
8. customA white solid was obtained (yield: 52 g)