反应详情

Tin(II) chloride (4.77 g) was added to a solution of ethyl 3-benzenesulphonylamino3-(3-nitrophenyl)-propionate from II.4a (2.0 g) in 60 ml of ethanol and the reaction mixture was heated under reflux for 2 h. After cooling, the solution was hydrolysed on ice and an NaHCO3 solution (5%) was added to pH=8. The mixture was then extracted with dichloromethane, and the org. phase was washed with NaCl, dried (MgSO4) and concentrated. A yellow oil was obtained (yield: 1.79 g).

1. temperaturethe reaction mixture was heated
2. temperatureunder reflux for 2 h
3. temperatureAfter cooling
4. extractionThe mixture was then extracted with dichloromethane
5. washphase was washed with NaCl
6. dry with materialdried (MgSO4)
7. concentrationconcentrated
8. customA yellow oil was obtained (yield: 1.79 g)