3-Nitro-[1,1'-biphenyl]-4-carbaldehyde → 3-Nitro[1,1'-biphenyl]-4-carboxylic acid

HRID 1353070ノート

反応式

HRID 1353070 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:7]=[CH:8][C:9]=1[CH:10]=[O:11])([O-:3])=[O:2].B1([O-])O[O:19]1.O.O.O.O.[Na+]>C(O)(=O)C>[N+:1]([C:4]1[CH:5]=[C:6]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:7]=[CH:8][C:9]=1[C:10]([OH:19])=[O:11])([O-:3])=[O:2]

参加物

4

反応物 2

HCID 179894023-Nitro-[1,1'-biphenyl]-4-carbaldehydeHCID 23693097Sodium;3-oxidodioxaborirane;tetrahydrate

生成物 1

HCID 179893243-Nitro[1,1'-biphenyl]-4-carboxylic acid収率 87%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
50 °C

実験手順

This aldehyde (454 mg, 2.0 mmol) was dissolved in acetic acid (10 ml) and treated with sodium perborate tetrahydrate (385 mg, 2.5 mmol), the mixture was heated to 50° C. for 48 h then cooled, concentrated to a paste and washed with water (2×50 ml). The residue was dried in a desiccator to afford 3-nitrobiphenyl-4-carboxylic acid as a white solid (420 mg, 87%);

後処理

  1. temperaturethen cooled
  2. concentrationconcentrated to a paste
  3. washwashed with water (2×50 ml)
  4. customThe residue was dried in a desiccator

出典と根拠

ORDレコード
ord-5fb6ea60eedb428b9e77297f424de7e9
出典データセット
uspto-grants-2007_05
特許番号
US07220777B2

反応ノート

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