3-Nitro-[1,1'-biphenyl]-4-carbaldehyde → 3-Nitro[1,1'-biphenyl]-4-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

This aldehyde (454 mg, 2.0 mmol) was dissolved in acetic acid (10 ml) and treated with sodium perborate tetrahydrate (385 mg, 2.5 mmol), the mixture was heated to 50° C. for 48 h then cooled, concentrated to a paste and washed with water (2×50 ml). The residue was dried in a desiccator to afford 3-nitrobiphenyl-4-carboxylic acid as a white solid (420 mg, 87%);

Provenance & Evidence