Oxalyl chloride → HCID 17989416, compound

HRID 1353089Notes

Reaction equation

HRID 1353089 reaction equation
[CH3:1][O:2][C:3]1[CH:13]=[C:12]([N+:14]([O-:16])=[O:15])[CH:11]=[CH:10][C:4]=1[O:5][CH2:6][C:7](O)=[O:8].C(Cl)(=O)C([Cl:20])=O>ClCCl>[CH3:1][O:2][C:3]1[CH:13]=[C:12]([N+:14]([O-:16])=[O:15])[CH:11]=[CH:10][C:4]=1[O:5][CH2:6][C:7]([Cl:20])=[O:8]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 19605571HCID 19605571, compound

Product 1

HCID 17989416HCID 17989416, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A suspension of (2-methoxy-4-nitro-phenoxy)acetic acid [FEBS Lett. (1983), 153(2), 431], (3.12 g 15.9 mmol) in dichloromethane (100 ml) was cooled down to 0° C. in an ice bath before oxalyl chloride (5.26 g, 41.7 mmol) was added. The reaction mixture was stirred for 45 minutes, giving a clear solution. The solvents were removed in vacuo to give (2-methoxy-4-nitro-phenoxy)-acetyl chloride as a pale yellow solid. (3.41 g, 100%);

Workup

  1. additionwas added
  2. customgiving a clear solution
  3. customThe solvents were removed in vacuo

Sources & evidence

ORD record
ord-9c910e45e461451d97c386a6d91ff106
Source dataset
uspto-grants-2007_05
Patent number
US07220777B2

Reaction notes

Loading…