反应详情

To a dioxane (15 ml) solution of the compound prepared in Example 10, pyridine (363 μl) and trifluoroacetic acid (423 μl) were added, followed by stirring at room temperature for 1 hour. The reaction mixture was concentrated, and the residue was diluted with ethyl acetate. The diluted solution was washed with 1 N hydrochloric acid, water and a saturated saline in this order, dried with anhydrous magnesium sulfate, and concentrated. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1) to thereby obtain the title compound (533 mg) having the following physical data.

1. concentrationThe reaction mixture was concentrated
2. additionthe residue was diluted with ethyl acetate
3. washThe diluted solution was washed with 1 N hydrochloric acid, water
4. dry with materiala saturated saline in this order, dried with anhydrous magnesium sulfate
5. concentrationconcentrated
6. customThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1)