Sodium Hydroxide → HCID 21102440, compound

HRID 1353186Notes

Reaction equation

HRID 1353186 reaction equation
C([O:3][C:4](=[O:44])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13]/[CH:14]=[CH:15]/[C:16]#[C:17][C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([C:24]#[C:25]/[CH:26]=[CH:27]/[CH2:28][O:29][C:30]3[CH:35]=[CH:34][C:33]([CH2:36][C:37]([O:39]CC)=[O:38])=[CH:32][C:31]=3[Cl:42])[CH:19]=2)=[C:8]([Cl:43])[CH:7]=1)C.[OH-].[Na+]>C1COCC1.C(O)C>[C:37]([CH2:36][C:33]1[CH:34]=[CH:35][C:30]([O:29][CH2:28]/[CH:27]=[CH:26]/[C:25]#[C:24][C:20]2[CH:19]=[C:18]([C:17]#[C:16]/[CH:15]=[CH:14]/[CH2:13][O:12][C:9]3[CH:10]=[CH:11][C:6]([CH2:5][C:4]([OH:44])=[O:3])=[CH:7][C:8]=3[Cl:43])[CH:23]=[CH:22][CH:21]=2)=[C:31]([Cl:42])[CH:32]=1)([OH:39])=[O:38]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 58864660HCID 58864660, compound

Product 1

HCID 21102440HCID 21102440, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of (E)(E) [3-chloro-4-(5-{3-[5-(2-chloro-4-ethoxycarbonylmethyl-phenoxy)-pent-3-en-1-ynyl]-phenyl}-pent-2-en-4-ynyloxy)-phenyl]-acetic acid ethyl ester (example 7) (180 mg 0.28 mmol) in THF (3 mL) and ethanol (3 mL) was added 1N sodium hydroxide (1.5 mL).

Sources & evidence

ORD record
ord-bbdf70018b934e57b203dac85ccfe2ee
Source dataset
uspto-grants-2007_05
Patent number
US07220877B2

Reaction notes

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