1-(4-Fluorobenzyl)piperazine → HCID 58646609, compound

HRID 1353289Notes

Reaction equation

HRID 1353289 reaction equation
[F:1][C:2]1[CH:14]=[CH:13][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)=[CH:4][CH:3]=1.[CH2:15]([O:17][C@@H:18]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([O:29][C@@H:30]([C:32](=[O:49])NCCC2C=CC(OC3C=CC=CC=3)=CC=2)C)=[CH:25][CH:24]=1)[C:19]([OH:21])=[O:20])C>>[F:1][C:2]1[CH:14]=[CH:13][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][N:10]([C:32](=[O:49])[CH2:30][O:29][C:26]3[CH:25]=[CH:24][C:23]([CH2:22][C@H:18]([O:17][CH3:15])[C:19]([OH:21])=[O:20])=[CH:28][CH:27]=3)[CH2:9][CH2:8]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 7965631-(4-Fluorobenzyl)piperazineHCID 9847886(2S,1R)-2-ethoxy-3-(4-{1-[2-(4-phenoxy-phenyl)-ethylcarbamoyl]-ethoxy}-phenyl)propionic acid

Product 1

HCID 58646609HCID 58646609, compound

Procedure

The title compound was prepared from (2S)-3-(4-carboxymethoxy-phenyl)-2-methoxy-ropionic acid ethyl ester (PREPARATION 3, step 2) and 1-(4-fluoro-benzyl)-piperazine via the same procedure used for the preparation of (2S,1R)-2-ethoxy-3-(4-{1-[2-(4-phenoxy-phenyl)-ethylcarbamoyl]-ethoxy}-phenyl)-propionic acid (Example 1, step 3) to produce a colorless oil. MS (ES) for C23H27FN2O5 [M+H]+: 431.

Workup

  1. customto produce a colorless oil

Sources & evidence

ORD record
ord-3485828556d5499db7b1abee0d9c4354
Source dataset
uspto-grants-2007_05
Patent number
US07220880B2

Reaction notes

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