Cyclobutylamine → HCID 58646637, compound

HRID 1353294Notes

Reaction equation

HRID 1353294 reaction equation
C(OC(=O)[C@@H](OC)CC1C=CC(OCC(O)=O)=CC=1)C.C1(N)CCC1.[CH2:26]([O:28][C@@H:29]([CH2:33][C:34]1[CH:39]=[CH:38][C:37]([O:40][C@@H:41]([C:43](=[O:60])[NH:44][CH2:45][CH2:46][C:47]2[CH:52]=CC(OC3C=CC=CC=3)=CC=2)C)=[CH:36][CH:35]=1)[C:30]([OH:32])=[O:31])C>>[CH:45]1([NH:44][C:43]([CH2:41][O:40][C:37]2[CH:36]=[CH:35][C:34]([CH2:33][C@H:29]([O:28][CH3:26])[C:30]([OH:32])=[O:31])=[CH:39][CH:38]=2)=[O:60])[CH2:46][CH2:47][CH2:52]1

Participants

4

Reactant 3

HCID 75645CyclobutylamineHCID 9847886(2S,1R)-2-ethoxy-3-(4-{1-[2-(4-phenoxy-phenyl)-ethylcarbamoyl]-ethoxy}-phenyl)propionic acidHCID 58864673(2S)-3-(4-carboxymethoxy-phenyl)-2-methoxy-propionic acid ethyl ester

Product 1

HCID 58646637HCID 58646637, compound

Procedure

The title compound was prepared from (2S)-3-(4-carboxymethoxy-phenyl)-2-methoxy-propionic acid ethyl ester (PREPARATION 3, step 2) and cyclobutylamine via the same procedure used for the preparation of (2S,1R)-2-ethoxy-3-(4-{1-[2-(4-phenoxy-phenyl)-ethylcarbamoyl]-ethoxy}-phenyl)-propionic acid (Example 1, step 3) to produce a colorless oil. MS (ES) for C16H21NO5 [M−H]−: 306.

Workup

  1. customto produce a colorless oil

Sources & evidence

ORD record
ord-a518bdd05d634f9c8c134acb34c75010
Source dataset
uspto-grants-2007_05
Patent number
US07220880B2

Reaction notes

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