Isoamylamine → HCID 58646627, compound

HRID 1353298Notes

Reaction equation

HRID 1353298 reaction equation
C(OC(=O)[C@@H](OC)CC1C=CC(OCC(O)=O)=CC=1)C.CC(C)CCN.[CH2:27]([O:29][C@@H:30]([CH2:34][C:35]1[CH:40]=[CH:39][C:38]([O:41][C@@H:42]([C:44](=[O:61])[NH:45][CH2:46][CH2:47][C:48]2[CH:53]=CC(OC3C=CC=CC=3)=C[CH:49]=2)C)=[CH:37][CH:36]=1)[C:31]([OH:33])=[O:32])C>>[CH3:27][O:29][C@@H:30]([CH2:34][C:35]1[CH:40]=[CH:39][C:38]([O:41][CH2:42][C:44](=[O:61])[NH:45][CH2:46][CH2:47][CH:48]([CH3:49])[CH3:53])=[CH:37][CH:36]=1)[C:31]([OH:33])=[O:32]

Participants

4

Reactant 3

HCID 7894IsoamylamineHCID 9847886(2S,1R)-2-ethoxy-3-(4-{1-[2-(4-phenoxy-phenyl)-ethylcarbamoyl]-ethoxy}-phenyl)propionic acidHCID 58864673(2S)-3-(4-carboxymethoxy-phenyl)-2-methoxy-propionic acid ethyl ester

Product 1

HCID 58646627HCID 58646627, compound

Procedure

The title compound was prepared from (2S)-3-(4-carboxymethoxy-phenyl)-2-methoxy-propionic acid ethyl ester (PREPARATION 3, step 2) and 3-methyl-butylamine via the same procedure used for the preparation of (2S,1R)-2-ethoxy-3-(4-{1-[2-(4-phenoxy-phenyl)-ethylcarbamoyl]-ethoxy}-phenyl)-propionic acid (Example 1, step 3) to produce a colorless oil. MS (ES) for C17H25NO5 [M−H]−: 322.

Workup

  1. customto produce a colorless oil

Sources & evidence

ORD record
ord-74958fa6340e4b64a322a7e6034e3561
Source dataset
uspto-grants-2007_05
Patent number
US07220880B2

Reaction notes

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