4-Fluorophenyl isocyanate → HCID 21101691, compound

HRID 1353317Notes

Reaction equation

HRID 1353317 reaction equation
[CH3:1][O:2][C:3]1[C:12](C)=[C:11]2[C:6]([C:7]([N:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1.[F:20][C:21]1[CH:26]=[CH:25][C:24]([N:27]=[C:28]=[O:29])=[CH:23][CH:22]=1.[CH3:30]CCCCC.CCOC(C)=O>C1COCC1>[F:20][C:21]1[CH:26]=[CH:25][C:24]([NH:27][C:28]([N:17]2[CH2:16][CH2:15][N:14]([C:7]3[C:6]4[C:11](=[CH:12][C:3]([O:2][CH3:1])=[CH:4][CH:5]=4)[N:10]=[C:9]([CH3:30])[CH:8]=3)[CH2:19][CH2:18]2)=[O:29])=[CH:23][CH:22]=1

Participants

5

Reactant 3

HCID 709554-Fluorophenyl isocyanateHCID 21101969HCID 21101969, compoundHCID 21226206Ethyl acetate hexane

Product 1

HCID 21101691HCID 21101691, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

7-Methoxy-8-methyl-4-(piperazin-1-yl)quinoline (0.20 g, 0.8 mmol) and 4-fluorophenyl isocyanate (102 μL, 0.9 mmol) in THF (10 mL) are reacted according to method C yielding the product as a yellow solid after column chromatography with hexane-EtOAc.

Sources & evidence

ORD record
ord-dd69ee8092e742aca9c807079a30b141
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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