HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → 4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]-7-nitroquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | 4-Chloro-7-nitroquinoline | HCID 12322580 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]-7-nitroquinoline | HCID 21101707 | — |
Reaction Steps
4-Chloro-7-nitroquinoline (Ellis, J.; Gellert, E.; Robson, J. Aust. J. Chem. 1973, 26, 907) (1.8 g, 8.7 mmol) and 1-tert-butoxycarbonylpiperazine (5.0 g, 27 mmol) are reacted according to method A furnishing 0.36 g of the piperazine as brown oil after column chromatography with CH2Cl2-MeOH.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220856B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-0c748ad56f184a28abf37efb0bc3d777 |
| Source note | uspto-grants-2007_05 |