Lithium Hydroxide → HCID 21101788, compound

Participants

Reaction Steps

A solution of ethyl 7-chloro-4-[4-(4-fluorophenylaminocarbonyl)piperazin-1-yl]quinoline-2-carboxylate (389 mg, 0.85 mmol) in THF-water 3:1 (5 mL) is treated with LiOH x H2O (126 mg, 3 mmol) and stirred at room temp. for 4 h. The reaction mixture is concentrated and acidified with 1 N HCl (pH 4). The colorless precipitate is collected by filtration yielding the title product.

Provenance & Evidence