Lithium Hydroxide → HCID 21101788, compound

HRID 1353328Notes

Reaction equation

HRID 1353328 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:17]3[CH2:22][CH2:21][N:20]([C:23]([NH:25][C:26]4[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=4)=[O:24])[CH2:19][CH2:18]3)=[CH:7][C:8]([C:12]([O:14]CC)=[O:13])=[N:9]2)=[CH:4][CH:3]=1.[Li+].[OH-]>C1COCC1.O>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:17]3[CH2:22][CH2:21][N:20]([C:23]([NH:25][C:26]4[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=4)=[O:24])[CH2:19][CH2:18]3)=[CH:7][C:8]([C:12]([OH:14])=[O:13])=[N:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 21101815HCID 21101815, compound

Product 1

HCID 21101788HCID 21101788, compound

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Procedure

A solution of ethyl 7-chloro-4-[4-(4-fluorophenylaminocarbonyl)piperazin-1-yl]quinoline-2-carboxylate (389 mg, 0.85 mmol) in THF-water 3:1 (5 mL) is treated with LiOH x H2O (126 mg, 3 mmol) and stirred at room temp. for 4 h. The reaction mixture is concentrated and acidified with 1 N HCl (pH 4). The colorless precipitate is collected by filtration yielding the title product.

Workup

  1. concentrationThe reaction mixture is concentrated
  2. filtrationThe colorless precipitate is collected by filtration

Sources & evidence

ORD record
ord-21a4f4098449429d9c394651b1a5fb52
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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