HCID 21101706, compound → HCID 21101785, compound

HRID 1353334Notes

Reaction equation

HRID 1353334 reaction equation
C([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:23]3[C:18](=[CH:19][C:20]([Cl:24])=[CH:21][CH:22]=3)[NH:17][C:16](=[O:25])[CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[C:26](O)([C:28]([F:31])(F)F)=O.C(Cl)Cl>FC1C=CC(N=C=O)=CC=1>[Cl:24][C:20]1[CH:19]=[C:18]2[C:23]([C:14]([N:11]3[CH2:10][CH2:9][N:8]([C:6]([NH:11][C:14]4[CH:23]=[CH:26][C:28]([F:31])=[CH:16][CH:15]=4)=[O:5])[CH2:13][CH2:12]3)=[CH:15][C:16](=[O:25])[NH:17]2)=[CH:22][CH:21]=1

Participants

4

Reactant 2

HCID 21101706HCID 21101706, compoundHCID 21863450Trifluoroacetic acid methylene chloride

Product 1

HCID 21101785HCID 21101785, compound

Reagents, catalysts & solvents 1

HCID 709554-Fluorophenyl isocyanateSolvent

Procedure

4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]-7-chloro-2-quinolone (100 mg) is deprotected with TFA-CH2Cl2 1:1 (0.5 mL) and transformed to the title product with 4-fluorophenyl isocyanate (50 μL) according to method C.

Sources & evidence

ORD record
ord-d437eeb49f114741a527fb1c58b8534c
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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