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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1353343Generated: November 1, 2026

Trifluoroacetic acid → HCID 21101784, compound

https://huagongshe.com/reaction/1353343

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantHCID 21101705HCID 21101705—
SolventDichloromethaneHCID 6344—
ProductHCID 21101784HCID 21101784—

Reaction Steps

4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]-7-chloro-2-(n-propylamino)quinoline (25 mg, 0.06 mmol) is deprotected with TFA in CH2Cl2 and transformed into the title product according to method C using 4-fluorophenyl isocyanate (10 μL, 0.09 mmol) and triethylamine (60 μL, 0.43 mmol) to give a colorless solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07220856B2
Source datasetuspto-grants-2007_05
ORD IDord-81f23f2ff6a94991b29dd54588566367
Source noteuspto-grants-2007_05