Trifluoroacetic acid → HCID 21101784, compound

HRID 1353343Notes

Reaction equation

HRID 1353343 reaction equation
C([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:23]3[C:18](=[CH:19][C:20]([Cl:24])=[CH:21][CH:22]=3)[N:17]=[C:16]([NH:25][CH2:26][CH2:27][CH3:28])[CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[C:29](O)([C:31]([F:34])(F)F)=O>C(Cl)Cl>[Cl:24][C:20]1[CH:19]=[C:18]2[C:23]([C:14]([N:11]3[CH2:12][CH2:13][N:8]([C:6]([NH:11][C:14]4[CH:23]=[CH:29][C:31]([F:34])=[CH:16][CH:15]=4)=[O:5])[CH2:9][CH2:10]3)=[CH:15][C:16]([NH:25][CH2:26][CH2:27][CH3:28])=[N:17]2)=[CH:22][CH:21]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 21101705HCID 21101705, compound

Product 1

HCID 21101784HCID 21101784, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]-7-chloro-2-(n-propylamino)quinoline (25 mg, 0.06 mmol) is deprotected with TFA in CH2Cl2 and transformed into the title product according to method C using 4-fluorophenyl isocyanate (10 μL, 0.09 mmol) and triethylamine (60 μL, 0.43 mmol) to give a colorless solid.

Sources & evidence

ORD record
ord-81f23f2ff6a94991b29dd54588566367
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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