Trifluoroacetic acid → HCID 21101783, compound

HRID 1353349Notes

Reaction equation

HRID 1353349 reaction equation
C(O[C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:23]3[C:18](=[CH:19][C:20]([Cl:24])=[CH:21][CH:22]=3)[N:17]=[C:16]([NH:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[CH:15]=2)[CH2:10][CH2:9]1)=[O:7])(C)(C)C.[C:31](O)([C:33]([F:36])(F)F)=O>C(Cl)Cl>[Cl:24][C:20]1[CH:19]=[C:18]2[C:23]([C:14]([N:11]3[CH2:10][CH2:9][N:8]([C:6]([NH:11][C:14]4[CH:23]=[CH:31][C:33]([F:36])=[CH:16][CH:15]=4)=[O:7])[CH2:13][CH2:12]3)=[CH:15][C:16]([NH:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])=[N:17]2)=[CH:22][CH:21]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 21101704HCID 21101704, compound

Product 1

HCID 21101783HCID 21101783, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]-7-chloro-2-(n-pentylamino)quinoline (68 mg, 0.11 mmol) is deprotected with TFA in CH2Cl2 and transformed into the title product according to method C using 4-fluorophenyl isocyanate (18 μL, 0.16 mmol) and triethylamine (110 μL, 0.79 mmol) to give a colorless solid.

Sources & evidence

ORD record
ord-1dfeb78018224daba9c1f8e50cf3585e
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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