4-Fluorophenyl isocyanate → HCID 21101772, compound

HRID 1353352Notes

Reaction equation

HRID 1353352 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:17][CH2:16][NH:15][CH:14]([CH3:18])[CH2:13]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[F:19][C:20]1[CH:25]=[CH:24][C:23]([N:26]=[C:27]=[O:28])=[CH:22][CH:21]=1.CCCCCC.CCOC(C)=O>C(Cl)Cl>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:17][CH2:16][N:15]([C:27]([NH:26][C:23]4[CH:24]=[CH:25][C:20]([F:19])=[CH:21][CH:22]=4)=[O:28])[CH:14]([CH3:18])[CH2:13]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 709554-Fluorophenyl isocyanateHCID 21101961HCID 21101961, compoundHCID 21226206Ethyl acetate hexane

Product 1

HCID 21101772HCID 21101772, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

7-Chloro-4-(3-methylpiperazin-1-yl)quinoline (0.13 g, 0.5 mmol) and 4-fluorophenyl isocyanate (57 μL, 0.5 mmol) in CH2Cl2 (10 mL) are reacted according to method C yielding the title product after column chromatography with hexane-EtOAc.

Sources & evidence

ORD record
ord-4e0791e4226c4f1fac0c357e1bdce9ad
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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