4-Fluorophenyl isocyanate → HCID 21101749, compound

HRID 1353356Notes

Reaction equation

HRID 1353356 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:17][CH:16]([CH3:18])[NH:15][CH:14]([CH3:19])[CH2:13]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[F:20][C:21]1[CH:26]=[CH:25][C:24]([N:27]=[C:28]=[O:29])=[CH:23][CH:22]=1>C(Cl)Cl.CO>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:13][CH:14]([CH3:19])[N:15]([C:28]([NH:27][C:24]4[CH:25]=[CH:26][C:21]([F:20])=[CH:22][CH:23]=4)=[O:29])[CH:16]([CH3:18])[CH2:17]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 709554-Fluorophenyl isocyanateHCID 21101960HCID 21101960, compound

Product 1

HCID 21101749HCID 21101749, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

7-Chloro-4-(3,5-dimethylpiperazin-1-yl)quinoline (100 mg, 0.36 mmol) and 4-fluorophenyl isocyanate (70 mg, 0.51 mmol) are reacted according to method C yielding the title product as colorless solid after column chromatography with CH2Cl2-MeOH.

Sources & evidence

ORD record
ord-11608132e6a84c5db0283b369d94c6ba
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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