HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorophenyl isocyanate → 7-Chloro-4-[5-(4-fluorophenylaminocarbonyl)-2,5-diazanorbornan-2-yl]quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorophenyl isocyanate | HCID 70955 | — |
| Reactant | 7-Chloro-4-(2,5-diazanorborn-2-yl)quinoline | HCID 21101959 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 7-Chloro-4-[5-(4-fluorophenylaminocarbonyl)-2,5-diazanorbornan-2-yl]quinoline | HCID 21101809 | — |
Reaction Steps
7-Chloro-4-(2,5-diazanorborn-2-yl)quinoline (110 mg, 0.42 mmol) and 4-fluorophenyl isocyanate (67 μL, 0.59 mmol) are reacted according to method C yielding the title product as a colorless solid after column chromatography with CH2Cl2-MeOH.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220856B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-61b11e9f6a80460ca480cb5c1ef3636a |
| Source note | uspto-grants-2007_05 |