7-Chloro-4-(piperazin-1-yl)quinoline → HCID 21101696, compound

HRID 1353365Notes

Reaction equation

HRID 1353365 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[CH2:18]([C:22]1[CH:27]=[CH:26][C:25]([N:28]=[C:29]=[O:30])=[CH:24][CH:23]=1)[CH2:19][CH2:20][CH3:21].CCCCCC.CCOC(C)=O>C1COCC1>[CH2:18]([C:22]1[CH:27]=[CH:26][C:25]([NH:28][C:29]([N:15]2[CH2:16][CH2:17][N:12]([C:6]3[C:5]4[C:10](=[CH:11][C:2]([Cl:1])=[CH:3][CH:4]=4)[N:9]=[CH:8][CH:7]=3)[CH2:13][CH2:14]2)=[O:30])=[CH:24][CH:23]=1)[CH2:19][CH2:20][CH3:21]

Participants

5

Reactant 3

HCID 7383897-Chloro-4-(piperazin-1-yl)quinolineHCID 27963134-Butylphenyl isocyanateHCID 21226206Ethyl acetate hexane

Product 1

HCID 21101696HCID 21101696, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

7-Chloro-4-(piperazin-1-yl)quinoline (62 mg, 0.25 mmol) and 4-(n-butyl)phenyl isocyanate (57 μL, 0.30 mmol) in THF (10 mL) are reacted according to method C yielding the title product as a colorless solid after column chromatography with hexane-EtOAc.

Sources & evidence

ORD record
ord-a4186498016b418c93a7df0ee6d322f2
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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