Benzyl isocyanate → HCID 21101699, compound

HRID 1353368Notes

Reaction equation

HRID 1353368 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[CH2:18]([N:25]=[C:26]=[O:27])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.CCCCCC.CCOC(C)=O>C1COCC1>[CH2:18]([NH:25][C:26]([N:15]1[CH2:16][CH2:17][N:12]([C:6]2[C:5]3[C:10](=[CH:11][C:2]([Cl:1])=[CH:3][CH:4]=3)[N:9]=[CH:8][CH:7]=2)[CH2:13][CH2:14]1)=[O:27])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

5

Reactant 3

HCID 76639Benzyl isocyanateHCID 7383897-Chloro-4-(piperazin-1-yl)quinolineHCID 21226206Ethyl acetate hexane

Product 1

HCID 21101699HCID 21101699, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

7-Chloro-4-(piperazin-1-yl)quinoline (62 mg, 0.25 mmol) and benzyl isocyanate (37 μL, 0.30 mmol) in THF (10 mL) are reacted according to method C yielding the title product as a colorless oil after column chromatography with hexane-EtOAc.

Sources & evidence

ORD record
ord-7302733e59ad4108bb32c52ad951e243
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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