Diisopropylethylamine → HCID 21101767, compound

HRID 1353381Notes

Reaction equation

HRID 1353381 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:17][CH2:16][N:15]([C:18]([NH:20][C:21]4[CH:26]=[CH:25][C:24](C(F)(F)F)=[CH:23][CH:22]=4)=[O:19])[CH2:14][CH2:13]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.ClC1C=C2C(C(N3CCNCC3)=CC=N2)=CC=1.C(N(C(C)C)CC)(C)C.[CH2:57]([O:59]C1C=CC(N=C=O)=CC=1)[CH3:58]>C(Cl)Cl.CO>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:13][CH2:14][N:15]([C:18]([NH:20][C:21]4[CH:26]=[CH:25][C:24]([O:59][CH2:57][CH3:58])=[CH:23][CH:22]=4)=[O:19])[CH2:16][CH2:17]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 81531DiisopropylethylamineHCID 122887Benzene, 1-ethoxy-4-isocyanato-HCID 7383897-Chloro-4-(piperazin-1-yl)quinolineHCID 2809985HCID 2809985, compound

Product 1

HCID 21101767HCID 21101767, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

As described for 7-chloro-4-[4-(4-trifluoromethylphenylaminocarbonyl)piperazin-1-yl]quinoline, 7-chloro-4-(piperazin-1-yl)quinoline (150 mg, 0.61 mmol), diisopropyl(ethyl)amine (158 mg, 1.22 mmol), and 4-ethoxyphenyl isocyanate (119 mg, 0.73 mmol) are reacted to give the title product after flash chromatography with CH2Cl2-MeOH.

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-ab1ca65a2e5d4b2aa12074126fdb0857
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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