Diisopropylethylamine → HCID 21101794, compound

HRID 1353382Notes

Reaction equation

HRID 1353382 reaction equation
ClC1C=C2C(C(N3CCN(C(NC4C=CC(C(F)(F)F)=CC=4)=O)CC3)=CC=N2)=CC=1.[Cl:31][C:32]1[CH:41]=[C:40]2[C:35]([C:36]([N:42]3[CH2:47][CH2:46][NH:45][CH2:44][CH2:43]3)=[CH:37][CH:38]=[N:39]2)=[CH:34][CH:33]=1.C(N(C(C)C)CC)(C)C.[CH:57]([C:60]1[CH:65]=[CH:64][C:63]([N:66]=[C:67]=[O:68])=[CH:62][CH:61]=1)([CH3:59])[CH3:58]>C(Cl)Cl.CO>[Cl:31][C:32]1[CH:41]=[C:40]2[C:35]([C:36]([N:42]3[CH2:47][CH2:46][N:45]([C:67]([NH:66][C:63]4[CH:64]=[CH:65][C:60]([CH:57]([CH3:59])[CH3:58])=[CH:61][CH:62]=4)=[O:68])[CH2:44][CH2:43]3)=[CH:37][CH:38]=[N:39]2)=[CH:34][CH:33]=1

Participants

6

Reactant 4

HCID 81531DiisopropylethylamineHCID 94416p-Isopropylphenyl isocyanateHCID 7383897-Chloro-4-(piperazin-1-yl)quinolineHCID 2809985HCID 2809985, compound

Product 1

HCID 21101794HCID 21101794, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

As described for 7-chloro-4-[4-(4-trifluoromethylphenylaminocarbonyl)piperazin-1-yl]quinoline, 7-chloro-4-(piperazin-1-yl)quinoline (150 mg, 0.61 mmol), diisopropyl(ethyl)amine (158 mg, 1.22 mmol), and 4-isopropylphenyl isocyanate (117 mg, 0.73 mmol) are reacted to give the title product after flash chromatography with CH2Cl2-MeOH.

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-a46155dcabcd4810882554c450121e5f
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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