Diisopropylethylamine → HCID 21101766, compound

HRID 1353384Notes

Reaction equation

HRID 1353384 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:17][CH2:16][N:15]([C:18]([NH:20][C:21]4[CH:26]=[CH:25][C:24](C(F)(F)F)=[CH:23][CH:22]=4)=[O:19])[CH2:14][CH2:13]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.ClC1C=[C:40]2C(C(N3CCNCC3)=C[CH:38]=[N:39]2)=CC=1.C(N(C(C)C)CC)(C)C.CN(C)C1C=CC(N=C=O)=CC=1>C(Cl)Cl.CO>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:17][CH2:16][N:15]([C:18]([NH:20][C:21]4[CH:22]=[CH:23][C:24]([N:39]([CH3:40])[CH3:38])=[CH:25][CH:26]=4)=[O:19])[CH2:14][CH2:13]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 81531DiisopropylethylamineHCID 7383897-Chloro-4-(piperazin-1-yl)quinolineHCID 27333724-(Dimethylamino)phenyl isocyanateHCID 2809985HCID 2809985, compound

Product 1

HCID 21101766HCID 21101766, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

As described for 7-chloro-4-[4-(4-trifluoromethylphenylaminocarbonyl)piperazin-1-yl]quinoline, 7-chloro-4-(piperazin-1-yl)quinoline (200 mg, 0.81 mmol), diisopropyl(ethyl)amine (209 mg, 1.62 mmol), and 4-(dimethylamino)phenyl isocyanate (157 mg, 0.97 mmol) are reacted to give the title product after flash chromatography with CH2Cl2-MeOH.

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-26327ca390a74acba05be46dd5c01789
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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