Cyclohexyl isocyanate → HCID 21101800, compound

HRID 1353388Notes

Reaction equation

HRID 1353388 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:17][CH2:16][N:15]([C:18]([NH:20][C:21]4[CH:26]=[CH:25][C:24](C(F)(F)F)=[CH:23][CH:22]=4)=[O:19])[CH2:14][CH2:13]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.ClC1C=C2C(C(N3CCNCC3)=CC=N2)=CC=1.C(N(C(C)C)CC)(C)C.C1(N=C=O)CCCCC1>C(Cl)Cl.CO>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:17][CH2:16][N:15]([C:18]([NH:20][CH:21]4[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]4)=[O:19])[CH2:14][CH2:13]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 18502Cyclohexyl isocyanateHCID 81531DiisopropylethylamineHCID 7383897-Chloro-4-(piperazin-1-yl)quinolineHCID 2809985HCID 2809985, compound

Product 1

HCID 21101800HCID 21101800, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

As described for 7-chloro-4-[4-(4-trifluoromethylphenylaminocarbonyl)piperazin-1-yl]quinoline, 7-chloro-4-(piperazin-1-yl)quinoline (200 mg, 0.81 mmol), diisopropyl(ethyl)amine (125 mg, 0.97 mmol), and cyclohexyl isocyanate (121 mg, 0.97 mmol) are reacted to give the title product after flash chromatography with CH2Cl2-MeOH.

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-107d017f5c6b43b09011da4ecf7c22b7
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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