7-Chloro-4-(piperazin-1-yl)quinoline → HCID 21101697, compound

HRID 1353389Notes

Reaction equation

HRID 1353389 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[C:18]12([N:28]=[C:29]=[O:30])[CH2:27][CH:22]3[CH2:23][CH:24]([CH2:26][CH:20]([CH2:21]3)[CH2:19]1)[CH2:25]2.CCCCCC.CCOC(C)=O>C(Cl)Cl>[C:18]12([NH:28][C:29]([N:15]3[CH2:16][CH2:17][N:12]([C:6]4[C:5]5[C:10](=[CH:11][C:2]([Cl:1])=[CH:3][CH:4]=5)[N:9]=[CH:8][CH:7]=4)[CH2:13][CH2:14]3)=[O:30])[CH2:27][CH:22]3[CH2:23][CH:24]([CH2:26][CH:20]([CH2:21]3)[CH2:19]1)[CH2:25]2

Participants

5

Reactant 3

HCID 7383897-Chloro-4-(piperazin-1-yl)quinolineHCID 20599951-IsocyanatoadamantaneHCID 21226206Ethyl acetate hexane

Product 1

HCID 21101697HCID 21101697, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

7-Chloro-4-(piperazin-1-yl)quinoline (124 mg, 0.5 mmol) and 1-adamantyl isocyanate (89 mg, 0.5 mmol) in CH2Cl2 (5 mL) are reacted according to method C yielding the title product as a colorless solid after column chromatography with hexane-EtOAc.

Sources & evidence

ORD record
ord-1fc78abc1f354b0d82b165bb70b355f7
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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