Potassium tert-butoxide → HCID 87870131, compound

HRID 1353393Notes

Reaction equation

HRID 1353393 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:17][CH2:16][N:15]([C:18](=[N:26][C:27]#[N:28])[O:19][C:20]4C=CC=C[CH:21]=4)[CH2:14][CH2:13]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.CC(C)([O-])C.[K+]>CCO>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:17][CH2:16][N:15]([C:18](=[N:26][C:27]#[N:28])[O:19][CH2:20][CH3:21])[CH2:14][CH2:13]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 23665647Potassium tert-butoxideHCID 87869961HCID 87869961, compound

Product 1

HCID 87870131HCID 87870131, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

7-Chloro-4-[4-(cyanimino(phenoxy)methyl)piperazin-1-yl]quinoline (196 mg, 0.5 mmol) and potassium tert-butoxide (62 mg, 0.55 mmol) in EtOH (5 mL) are stirred at room temp. for 4 h. The reaction mixture is concentrated, and the residue purified by column chromatography delivering the title product.

Workup

  1. concentrationThe reaction mixture is concentrated
  2. customthe residue purified by column chromatography

Sources & evidence

ORD record
ord-b5ff85d316f94eb988f5d4a1f58271d4
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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