2-Chlorobenzimidazole → HCID 21101698, compound

HRID 1353398Notes

Reaction equation

HRID 1353398 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.Cl[C:19]1[NH:20][C:21]2[CH:27]=[CH:26][CH:25]=[CH:24][C:22]=2[N:23]=1>CCOC(C)=O.O>[N:20]1[C:21]2[CH:27]=[CH:26][CH:25]=[CH:24][C:22]=2[NH:23][C:19]=1[N:15]1[CH2:16][CH2:17][N:12]([C:6]2[C:5]3[C:10](=[CH:11][C:2]([Cl:1])=[CH:3][CH:4]=3)[N:9]=[CH:8][CH:7]=2)[CH2:13][CH2:14]1

Participants

4

Reactant 2

HCID 785722-ChlorobenzimidazoleHCID 7383897-Chloro-4-(piperazin-1-yl)quinoline

Product 1

HCID 21101698HCID 21101698, compound

Reagents, catalysts & solvents 1

HCID 22728543Water ethylacetateSolvent

Procedure

7-Chloro-4-(piperazin-1-yl)quinoline (247 mg, 1.0 mmol) and 2-chlorobenzimidazole (46 mg, 0.3 mmol) are heated at 150° C. for 1 h. The mixture is dissolved in EtOAc-water. The organic layer is separated, dried (MgSO4), and concentrated. Column chromatography of the residue with hexane-EtOAc furnishes the title product as colorless solid.

Workup

  1. customThe organic layer is separated
  2. dry with materialdried (MgSO4)
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-0b7cb530b74845f683751e16cad5c71e
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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