HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorobenzimidazole → HCID 21101698, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorobenzimidazole | HCID 78572 | — |
| Reactant | 7-Chloro-4-(piperazin-1-yl)quinoline | HCID 738389 | — |
| Solvent | Water ethylacetate | HCID 22728543 | — |
| Product | HCID 21101698 | HCID 21101698 | — |
Reaction Steps
7-Chloro-4-(piperazin-1-yl)quinoline (247 mg, 1.0 mmol) and 2-chlorobenzimidazole (46 mg, 0.3 mmol) are heated at 150° C. for 1 h. The mixture is dissolved in EtOAc-water. The organic layer is separated, dried (MgSO4), and concentrated. Column chromatography of the residue with hexane-EtOAc furnishes the title product as colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220856B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-0b7cb530b74845f683751e16cad5c71e |
| Source note | uspto-grants-2007_05 |