Diisopropylethylamine → HCID 58864174, compound

Participants

Role	Name	HCID	Charge
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	4-Nitrophenyl chloroformate	HCID 82129	—
Reactant	7-Chloro-4-(piperazin-1-yl)quinoline	HCID 738389	—
Reactant	tert-Butyl 4-aminoazepane-1-carboxylate	HCID 18946151	—
Product	HCID 58864174	HCID 58864174	—

Reaction Steps

As described for example 78, 4-amino-N-1-Boc-azepine, p-nitrophenyl chloroformate, diisopropylethyl amine and 7-chloro-4-piperazinylquinoline are reacted to afford the title product. LC-MS: 488 (M++1). 1H NMR (CDCl3) δ 8.75 (d, 1H), 8.05 (s, 1H), 7.96 (d, 1H), 7.45 (d, 1H), 6.85 (d, 1H), 4.55 (m, 1H), 4.05 (m, 1H), 3.90 (m, 1H), 3.60 (m, 4H), 3.30 (m, 1H), 3.20 (m, 4H), 3.10 (m, 2H), 2.10 (m, 1H), 1.60–1.90 (m, 3H), 1.50 (s, 9H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07220856B2
Source dataset	uspto-grants-2007_05
ORD ID	ord-ab454f42a8b84b3ba9950fe5160c3c24
Source note	uspto-grants-2007_05