HRID1353426

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID81531

Diisopropylethylamine

C8H19N

HCID82129

Carbonochloridic acid, 4-nitrophenyl ester

C7H4ClNO4

HCID738389

7-chloro-4-(piperazin-1-yl)quinoline

C13H14ClN3

HCID18946151

tert-Butyl 4-aminoazepane-1-carboxylate

C11H22N2O2

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CCCC(NC(=O)N2CCN(c3ccnc4cc(Cl)ccc34)CC2)CC1

HCID58864174

未命名化合物

PROCEDURE

实验过程

As described for example 78, 4-amino-N-1-Boc-azepine, p-nitrophenyl chloroformate, diisopropylethyl amine and 7-chloro-4-piperazinylquinoline are reacted to afford the title product. LC-MS: 488 (M++1). 1H NMR (CDCl3) δ 8.75 (d, 1H), 8.05 (s, 1H), 7.96 (d, 1H), 7.45 (d, 1H), 6.85 (d, 1H), 4.55 (m, 1H), 4.05 (m, 1H), 3.90 (m, 1H), 3.60 (m, 4H), 3.30 (m, 1H), 3.20 (m, 4H), 3.10 (m, 2H), 2.10 (m, 1H), 1.60–1.90 (m, 3H), 1.50 (s, 9H).

WORKUP

后处理

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