Diisopropylethylamine → HCID 58864174, compound

HRID 1353426Notes

Reaction equation

HRID 1353426 reaction equation
[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:14][CH2:13][CH:12]([NH2:15])[CH2:11][CH2:10][CH2:9]1)=[O:7])([CH3:4])[CH3:3].Cl[C:17](OC1C=CC([N+]([O-])=O)=CC=1)=[O:18].C(N(C(C)C)CC)(C)C.[Cl:38][C:39]1[CH:48]=[C:47]2[C:42]([C:43]([N:49]3[CH2:54][CH2:53][NH:52][CH2:51][CH2:50]3)=[CH:44][CH:45]=[N:46]2)=[CH:41][CH:40]=1>>[Cl:38][C:39]1[CH:48]=[C:47]2[C:42]([C:43]([N:49]3[CH2:54][CH2:53][N:52]([C:17]([NH:15][CH:12]4[CH2:11][CH2:10][CH2:9][N:8]([C:6]([O:5][C:2]([CH3:1])([CH3:3])[CH3:4])=[O:7])[CH2:14][CH2:13]4)=[O:18])[CH2:51][CH2:50]3)=[CH:44][CH:45]=[N:46]2)=[CH:41][CH:40]=1

Participants

5

Reactant 4

HCID 81531DiisopropylethylamineHCID 821294-Nitrophenyl chloroformateHCID 7383897-Chloro-4-(piperazin-1-yl)quinolineHCID 18946151tert-Butyl 4-aminoazepane-1-carboxylate

Product 1

HCID 58864174HCID 58864174, compound

Procedure

As described for example 78, 4-amino-N-1-Boc-azepine, p-nitrophenyl chloroformate, diisopropylethyl amine and 7-chloro-4-piperazinylquinoline are reacted to afford the title product. LC-MS: 488 (M++1). 1H NMR (CDCl3) δ 8.75 (d, 1H), 8.05 (s, 1H), 7.96 (d, 1H), 7.45 (d, 1H), 6.85 (d, 1H), 4.55 (m, 1H), 4.05 (m, 1H), 3.90 (m, 1H), 3.60 (m, 4H), 3.30 (m, 1H), 3.20 (m, 4H), 3.10 (m, 2H), 2.10 (m, 1H), 1.60–1.90 (m, 3H), 1.50 (s, 9H).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-ab454f42a8b84b3ba9950fe5160c3c24
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

Loading…