HCID 22480224, compound → HCID 22480316, compound

HRID 1353709Notes

Reaction equation

HRID 1353709 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1/[CH:7]=[CH:8]/[C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][N:13]=[C:12]2[C:18]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=1>CO>[F:24][C:21]1[CH:22]=[CH:23][C:18]([C:12]2[C:11]3[C:15](=[CH:16][CH:17]=[C:9]([CH2:8][CH2:7][C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=4)[CH:10]=3)[NH:14][N:13]=2)=[CH:19][CH:20]=1

Participants

3

Reactant 1

HCID 22480224HCID 22480224, compound

Product 1

HCID 22480316HCID 22480316, compoundYield 47%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound was prepared as described in Example 141 A, using 5-[(1 E)-2-pyridylvinyl]-3-(4-fluorophenyl)-1H-indazole (0.125 g, 0.4 mmol) in methanol and it was then purified by HPLC (0.060 g, 47% yield): 1H NMR (DMSO-d6) δ 13.14 (br s, 1H), 8.52 (d, 1H), 7.95 (m, 2H), 7.79 (s, 1H), 7.69 (ddd, 1H), 7.42 (dd, 1H), 7.22–7.35 (m, 5H), 3.12 (m, 4H); ES-MS (m/z) 318 [M+1]+.

Workup

  1. customwas then purified by HPLC (0.060 g, 47% yield)

Sources & evidence

ORD record
ord-128621ef9ec44b7791dc758dcdd984b1
Source dataset
uspto-grants-2007_05
Patent number
US07220771B2

Reaction notes

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