Hydrazine hydrate (1:1) → 1H-Indazole-5-carbonitrile

HRID 1353722Notes

Reaction equation

HRID 1353722 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([C:8]#[N:9])=[CH:4][C:3]=1[CH:10]=O.O.[NH2:13][NH2:14]>>[NH:13]1[C:2]2[C:3](=[CH:4][C:5]([C:8]#[N:9])=[CH:6][CH:7]=2)[CH:10]=[N:14]1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 109097255-Cyano-2-fluorobenzaldehyde

Product 1

HCID 111263841H-Indazole-5-carbonitrileYield 81%

Procedure

4-Fluoro-3-formylbenzenecarbonitrile (4.6 g, 30.85 mmol) was suspended in 20 mL of hydrazine mono-hydrate and the reaction mixture was stirred at room temperature for 48 hours. The title compound was isolated by filtration as a white solid, was washed with small portions of distilled water, and was dried in a vacuum (3.6 g, 81% yield).

Sources & evidence

ORD record
ord-646908dd7afb4916a6bc6dcbc80d5fde
Source dataset
uspto-grants-2007_05
Patent number
US07220771B2

Reaction notes

Loading…