Hydrochloric Acid → HCID 22480020, compound

HRID 1353768Notes

Reaction equation

HRID 1353768 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:17](=[O:19])[CH3:18])[CH:15]=3)[N:10](C3CCCCO3)[N:9]=2)=[CH:4][CH:3]=1.Cl>CO>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:17](=[O:19])[CH3:18])[CH:15]=3)[NH:10][N:9]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22480112HCID 22480112, compound

Product 1

HCID 22480020HCID 22480020, compoundYield 108.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a solution of 1-[3-(4-fluorophenyl)-1-perhydro-2H-pyran-2-yl-1H-indazol-5-yl]ethan-1-one (100 mg, 0.30 mmol) in methanol (30 mL) was added 6 N HCl (30 mL). The solution was stirred at room temperature for 4.5 hours when the methanol was removed under vacuo and the solution made basic with saturated Na2CO3. The suspension was then filtered and the product dried to give the title compound (83 mg, 100% yield). 1H NMR (DMSO-d6) δ 8.64 (s, 1H), 8.1 (m, 2H), 7.97 (d, 1H), 7.67 (d, 1H), 7.40 (t, 2H), 2.69 20 (s, 3H); ES-MS (m/z) 255 [M+1]+.

Workup

  1. customwas removed under vacuo
  2. filtrationThe suspension was then filtered
  3. customthe product dried

Sources & evidence

ORD record
ord-f14474e1e2d94a0d8246de834c41c253
Source dataset
uspto-grants-2007_05
Patent number
US07220771B2

Reaction notes

Loading…